Pest Management Science (2014) 70, 286-294

Marcelina Mazur, Witold Gladkowski, Magdalena Podkowik, Jacek Bania, Jan Nawrot, Agata Bialonska and Czeslaw Wawrzenczyk (2014)
Lactones 43. New biologically active lactones: β-cyclocitral derivatives
Pest Management Science 70 (2), 286-294
Abstract:
BACKGROUND
In our previous studies bicyclic γ-lactones with cyclohexane ring exhibited high antifeedant activity against storage pests. The activity was correlated with the type and number of substituents in the cyclohexane ring. One of the most potent group of antifeedant agents was δ-iodo-γ-lactones.
RESULTS
We present the synthesis of new bicyclic γ-lactones with the cyclohexane ring containing different halogen atoms. To determine the impact of halogen type on biological activity the lactone without halogen atom was also synthesized. The lactones were tested for their antifeedant activity toward the granary weevil beetle (Sitophilus granarius L.), the khapra beetle (Trogoderma granarium Everts) and the confused flour beetle (Tribolium confusum Du Val.). The results of the tests proved that the highest activity was observed for chlorolactone (7) towards larvae and adults of Tribolium confusum. Antibacterial activity of new lactones was also evaluated. Lactone without halogen atom (8) was active against Staphylococcus aureus and Listeria monocytogenes.
CONCLUSIONS
Studies on the biological activity of synthesised lactones revealed high selectivity towards insect pests as well as bacterial strains. Only the halolactones exhibited significant antifeedant activity. In contrast, antibacterial activity was shown only by the lactone (8) without halogen.
(The abstract is excluded from the Creative Commons licence and has been copied with permission by the publisher.)
Link to article at publishers website
Database assignments for author(s): Jan Nawrot

Research topic(s) for pests/diseases/weeds:
pesticide resistance of pest

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Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Tribolium confusum
	Sitophilus granarius
	Trogoderma granarium