Journal of Economic Entomology (2008) 101, 1415-1420

Qi Fang, Cheng-Hua Huang, Gong-Yin Ye, Hong-Wei Yao, Jia-An Cheng and Zunnu-Raen Akhtar (2008)
Differential fipronil susceptibility and metabolism in two rice stem borers from China
Journal of Economic Entomology 101 (4), 1415-1420
Abstract: The susceptibilities of larvae of two rice stem borers, namely, Chilo suppressalis (Walker) (Lepidoptera: Crambidae) and Sesamia inferens (Walker) (Lepidoptera: Nocutidae) to fipronil and its metabolites were investigated, and then the activities of microsomal O-demethylase, and glutathione transferase (GST) in two species were measured. The metabolism of fipronil in both stem borers was determined in vivo and in vitro. The LD₅₀ value of fipronil to S. inferens was 118.5-fold higher than that of C. suppressalis. The bioassay results of fipronil metabolites showed that the toxicities of sulfone and sulfide were higher than fipronil for both species, and the differential toxicity between sulfone and fipronil was remarkable. Alternatively, the activities of microsomal O-demethylase and GST of C. suppressalis were 1.35- and 2.06-fold higher than S. inferens, respectively. The in vivo and in vitro studies on metabolism of fipronil showed that all of fipronil, sulfone, and sulfide were detected and the content of sulfone was higher than sulfide in both stem borers. The residue of sulfone in C. suppressalis was significantly higher than that in S. inferens. These results suggest that the higher activity of mixed function oxidases may cause the higher capacity of C. suppressalis to produce fipronil-sulfone, which is more toxic than fipronil leading to the higher susceptibility of this species.
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Link to article at publishers website
Database assignments for author(s): Jia-An Cheng

Research topic(s) for pests/diseases/weeds:
control - general

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Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Chilo suppressalis	Rice (Oryza)
	Sesamia inferens	Rice (Oryza)