Pest Management Science (2017) 73, 2048-2053

Simone Z. Mairink, Luiz C.A. Barbosa, Eduardo V.V. Varejão, Elizeu S. Farias, Márcio L.M. Santos and Marcelo C. Picanço (2017)
Larvicidal activity of synthetic tropane alkaloids against Ascia monuste orseis (Lepidoptera: Pieridae)
Pest Management Science 73 (10), 2048-2053
Abstract:
BACKGROUND
Tropane alkaloids are known to play a role in plant defence. By blocking acetylcholine receptors, they exert insecticidal and deterrent effects against herbivore insects. Carbamates are an important class of chemical insecticides that also inhibit acetyl cholinesterase. The objective of this work was to synthesise a series of tropane alkaloids bearing a carbamate group, and to evaluate their effects against the pest Ascia monuste. The effects of the most active compounds were evaluated on the A. monuste predator Solenopsis saevissima and on the pollinator Tetragonisca angustula.
RESULTS
The synthesis of carbamate-tropane alkaloids was accomplished in 4–5 steps from commercially available ketones. Results from bioassays showed that compounds 6a, 10a and 14a presented higher activities against second-instar larvae of A. monuste, with LD₅₀ values of 1.01, 3.76 and 1.92 µg substance mg^-1 insect, and TL₅₀ values of 7.0, 15.0 and 5.0 h respectively. These compounds were also tested for their selectivity in favour of S. saevissima and T. angustula. Compound 6a, which showed the highest activity against A. monuste, also showed lower toxicity against S. saevissima.
CONCLUSION
Tropane alkaloid derivatives bearing a carbamate group show potential for the development of novel insecticides against A. monuste.
(The abstract is excluded from the Creative Commons licence and has been copied with permission by the publisher.)
Link to article at publishers website
Database assignments for author(s): Marcelo Coutinho Picanco

Research topic(s) for pests/diseases/weeds:
control - general
health/environmental effects of pesticides
Research topic(s) for beneficials or antagonists:
resistance to pesticides

---

Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Ascia monuste
Solenopsis saevissima (predator)	Ascia monuste