Pest Management Science (2016) 72, 2069-2081

Antonio Cala, Kala Ghooray, Mónica Fernández-Aparicio, José M.G. Molinillo, Juan C.G. Galindo, Diego Rubiales and Francisco A. Macías (2016)
Phthalimide-derived strigolactone mimics as germinating agents for seeds of parasitic weeds
Pest Management Science 72 (11), 2069-2081
Abstract:
BACKGROUND
Broomrapes attack important crops, cause severe yield losses and are difficult to eliminate because their seed bank is virtually indestructible. In the absence of a host, the induction of seed germination leads to inevitable death due to nutrient starvation. Synthetic analogues of germination-inducing factors may constitute a cheap and feasible strategy to control the seed bank. These compounds should be easy and cheap to synthesise, as this will allow their mass production. The aim of this work is to obtain new synthethic germinating agents.
RESULTS
Nineteen N-substituted phthalimides containing a butenolide ring and different substituents in the aromatic ring were synthesised. The synthesis started with commercially available phthalimides. The complete collection was assayed against the parasitic weeds Orobanche minor, O. cumana, Phelipanche ramosa and P. aegyptiaca, with the synthetic strigolactone analogue GR24 used as a positive control. These compounds offered low EC₅₀ values: O. cumana 38.3 μM, O. minor 3.77 μM, P. aegyptiaca 1.35 μM and P. ramosa 1.49 μM.
CONCLUSIONS
The synthesis was carried out in a few steps and provided the target compounds in good yields. The compounds tested showed great selectivity, and low EC₅₀ values were obtained for structures that were simpler than GR24.
(The abstract is excluded from the Creative Commons licence and has been copied with permission by the publisher.)
Link to article at publishers website

Research topic(s) for pests/diseases/weeds:
control - general

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Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Orobanche cumana (weed)
	Phelipanche aegyptiaca (weed)
	Phelipanche ramosa (weed)
	Orobanche minor (weed)