Applied and Environmental Microbiology (2009) 75, 7548-7550

Carlos Muñoz-Garay, Claudia Rodríguez-Almazán, Jose N. Aguilar, Leivi Portugal, Isabel Gómez, Gloria Saab-Rincon, Mario Soberón and Alejandra Bravo (2009)
Oligomerization of Cry11Aa from Bacillus thuringiensis has an important role in toxicity against Aedes aegypti
Applied and Environmental Microbiology 75 (23), 7548-7550
Abstract: Cry11Aa and Cyt1Aa of Bacillus thuringiensis are active against mosquitoes and show synergism. Cyt1Aa functions as a membrane receptor inducing Cry11Aa oligomerization. Here we characterized Cry11Aa helix alpha-3 mutants impaired in oligomerization and toxicity against Aedes aegypti, indicating that oligomerization of Cry11Aa is important for toxin action. Cyt1Aa did not recover the insecticidal activity of Cry11Aa mutants.
(The abstract is excluded from the Creative Commons licence and has been copied with permission by the publisher.)
Link to article at publishers website
Database assignments for author(s): Alejandra Bravo

Research topic(s) for pests/diseases/weeds:
biocontrol - natural enemies
Research topic(s) for beneficials or antagonists:
molecular biology - genes
general biology - morphology - evolution

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Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Aedes aegypti
Bacillus thuringiensis Cyt1A-toxin (entomopathogen)	Aedes aegypti
Bacillus thuringiensis Cry11A-toxin (entomopathogen)	Aedes aegypti