REDIA (2018) 101, 115-121

Maria Elena Mura, Andrea Lentini and Luca Ruiu (2018)
Immunomodulation of house flies exposed to azadirachtin
REDIA 101, 115-121
Abstract: In this study the lethal and sub-lethal effects of azadirachtin on adult house flies, and the main variations in their immune-related gene expression levels were detected. Flies acquiring azadirachtin by ingestion showed different degrees of susceptibility depending on concentration and time of exposure to this compound, with LC50 value corresponding to 101.14 μg/ml, after five days of exposure to a dose of 7.5 μl/fly/day. Flies surviving ingestion of sublethal concentrations showed significant decrease in their lifespan and reproductive performance, including fecundity and percentage of egg hatching. A significant immune-stimulation effect of lower azadirachtin concentrations (25 μg/ml), and a general immunosuppression of most AMPs (i.e. attacin, cecropin, defensin, diptericin and muscin) at higher concentration levels (100 μg/ml) were observed. This study highlights the immunodeficiency potential of azadirachtin, providing new insights into understanding the physiological response of Musca domestica to this botanical compound at the molecular level.
(The abstract is excluded from the Creative Commons licence and has been copied with permission by the publisher.)
Link to article at publishers website
Database assignments for author(s): Luca Ruiu

Research topic(s) for pests/diseases/weeds:
pesticide resistance of pest
control - general

---

Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Musca domestica