Pesticide Science (1999) 55, 372-374

Makoto Kimura and Isamu Yamaguchi (1999)
The mystery of the trichothecene 3-O-acetyltransferase gene: Tri101 evolved independently of other trichothecene biosynthetic genes in the gene cluster
Pesticide Science 55 (3), 372-374
Abstract: Trichothecene resistance is achieved via 3-O-acetylation on the biosynthetic pathway of deoxynivalenol in Fusarium graminearum. The responsible 3-O-acetyltransferase gene, Tri101, was located between the UTP-ammonia ligase gene and the phosphate permease gene, and not in the trichothecene biosynthetic gene cluster. As predicted by the presence of its homologues in yeasts, the resistance gene proved to have evolved independently of other biosynthetic genes.
In Fusarium sporotrichioides, FsTri101 (a functional homologue of Tri101) was also located these two 'house-keeping genes'. However, FsTri101 appeared not to play a pivotal role for self-resistance, suggesting that other defensive options are the primary working strategies for the type A trichothecene producer.
(The abstract is excluded from the Creative Commons licence and has been copied with permission by the publisher.)

Research topic(s) for pests/diseases/weeds:
molecular biology - genes

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Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Fusarium graminearum
	Fusarium sporotrichioides