Pest Management Science (2011) 67, 986-992

Xing-Hai Li, Ming-Shan Ji, Zhi-Qiu Qi, Xiu-Wei Li, Yu-Xia Shen, Zu-Min Gu, Yang Zhang, Song-Hong Wei, Ying-Zi Wang and Dao-Quan Wang (2011)
Synthesis of 2-amino-6-oxocyclohexenyl- sulfonamides and their activity against Botrytis cinerea
Pest Management Science 67 (8), 986-992
Abstract: BACKGROUND: With the objective of exploring the fungicidal activity of 2-oxocyclohexylsulfonamides (2), a series of novel 2-amino-6-oxocyclohexenylsulfonamides (6 to 23) were synthesised, and their fungicidal activities against Botrytis cinerea Pers. were evaluated in vitro and in vivo.
RESULTS: The compounds were characterised by IR, ¹H NMR and elemental analysis. Bioassay results of mycelial growth showed that compounds 6 to 23 had a moderate antifungal activity against B. cinerea. N-(2-methylphenyl)-2-(2-methylphenylamino)-4,4-dimethyl-6-oxocyclohexenylsulfonamide (13) and N-(2-chlorophenyl)-2-(2-chlorophenylamino)-6-oxocyclohexenylsulfonamide (21) showed best antifungal activities, with EC₅₀ values of 8.05 and 10.56 µg mL⁻¹ respectively. Commercial fungicide procymidone provided an EC₅₀ value of 0.63 µg mL⁻¹. The conidial germination assay showed that most of compounds 6 to 23 possessed excellent inhibition of spore germination and germ-tube elongation of conidia of B. cinerea. For in vivo control of B. cinerea colonising cucumber leaves, the compound N-cyclohexyl-2-(cyclohexylamino)-4,4-dimethyl-6-oxocyclohexenylsulfonamide (19) showed a better control effect than the commercial fungicide procymidone.
CONCLUSION: The present work demonstrated that 2-amino-6-oxocyclohexenylsulfonamides can be used as possible new lead compounds for further developing novel fungicides against B. cinerea.
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Link to article at publishers website
Database assignments for author(s): Daoquan Wang

Research topic(s) for pests/diseases/weeds:
control - general

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Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Botrytis cinerea