Pest Management Science (2005) 61, 186-190

Samir A.M. Abdelgaleil, Fumio Hashinaga and Munehiro Nakatani (2005)
Antifungal activity of limonoids from Khaya ivorensis
Pest Management Science 61 (2), 186-190
Abstract: Chemical investigation of the diethyl ether extract of the stem bark of Khaya ivorensis A Chev (Meliaceae) afforded ten limonoids of angolensates, ring D-opened limonoids and mexicanolides. The structures of the limonoids isolated were determined by comparison of their ¹H and ¹³C NMR data with those reported in the literature. These compounds were evaluated for their antifungal activity against the plant pathogenic fungus Botrytis cinerea Pers. Methyl 6-hydroxyangolensate and 3,7-dideacetylkhivorin were also tested for their antifungal and antibacterial activities on several fungal and bacterial species. Methyl angolensate and 1,3,7-trideacetylkhivorin displayed the highest antifungal activity against B cinerea, with respectively 62.8 and 64.0% mycelial growth inhibition at 1000 mg litre^-1, and 73.3 and 68.6% mycelial growth inhibition at 1500 mg litre^-1. 3,7-Dideacetylkhivorin showed stronger antifungal and antibacterial activities than methyl 6-hydroxyangolensate against all of the test fungi and bacteria except Penicillium expansum Link. This is the first report on the antifungal and antibacterial effects of these limonoids. Structure-antifungal activity relationships of the limonoids isolated are discussed.
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Link to article at publishers website
Database assignments for author(s): Samir A.M. Abdelgaleil

Research topic(s) for pests/diseases/weeds:
control - general

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Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Botrytis cinerea
	Penicillium expansum