Pest Management Science (2000) 56, 65-73

Kazuo Yagi, Kazuhiko Akimoto, Norihiko Mimori, Toshiro Miyake, Masaki Kudo, Kazutaka Arai and Shigeru Ishii (2000)
Synthesis and insecticidal/acaricidal activity of novel 3-(2,4,6-trisubstituted phenyl)uracil derivatives
Pest Management Science 56 (1), 65-73
Abstract: A series of novel 3-(2,4,6-trisubstituted phenyl)uracil derivatives has been synthesised and assayed for insecticidal/acaricidal activity. The assay indicated certain requirements for optimal insecticidal activity, which can be summarised as follows: (a) the substituents on the phenyl ring should possess hydrophobicity and electron-withdrawing properties, and the sum of their volumes determines the level of activity; (b) the substituent at the 6-position on the uracil ring should also possess electron-withdrawing properties and hydrophobicity, together with the correct volume; (c) the 1-position on the uracil ring should be unsubstituted for activity against Nephotettix cincticeps and Epilachna vigintioctopunctata, but substituents with length C3 to C4 may be optimal for activity against Tetranychus urticae; (d) certain substituents at the 5-position of the uracil ring give activity against E vigintioctopunctata and T urticae, but not against N cincticeps; (e) a thiocarbonyl group at the 2-position of the uracil ring is less effective than a carbonyl group. Of the compounds assayed, 3-(2,6-dichloro-4-trifluoromethylphenyl)-6-trifluoromethyluracil showed high activity against all the species assayed.
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Research topic(s) for pests/diseases/weeds:
control - general

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Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Tetranychus urticae
	Nephotettix cincticeps
	Henosepilachna vigintioctopunctata