Molecular Plant-Microbe Interactions (2010) 23, 871-878

Yan Li, Akihiro Yamazaki, Lifang Zou, Eulandria Biddle, Quan Zeng, Yongjun Wang, Haiping Lin, Qi Wang and Ching-Hong Yang (2010)
ClpXP protease regulates the type III secretion system of Dickeya dadantii 3937 and is essential for the bacterial virulence
Molecular Plant-Microbe Interactions 23 (7), 871-878
Abstract: The type III secretion system (T3SS) is considered one of the major virulence factors in many bacterial pathogens. This report demonstrates that RssB, ClpXP, and RpoS play a role in T3SS regulation of Dickeya dadantii 3937. ClpP is a serine-type protease which associates with the ClpX chaperone to form a functional Clp proteolytic complex for degradation of proteins. With the assistance of recognition factor RssB, ClpXP degrades the RpoS sigma factor. RpoS positively regulates the expression of the rsmA gene encoding an RNA-binding regulatory protein. By interacting with the hrpL mRNA, RsmA reduces HrpL production and downregulates the T3SS genes in the HrpL regulon. In addition, ClpXP, RssB, and RpoS affect pectinolytic enzyme production in D. dadantii 3937, probably through RsmA. The ClpXP and RssB proteins are essential for bacterial virulence.
(The abstract is excluded from the Creative Commons licence and has been copied with permission by the publisher.)
Link to article at publishers website
Database assignments for author(s): Qi Wang, Ching-Hong Yang

Research topic(s) for pests/diseases/weeds:
molecular biology - genes

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Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Dickeya dadantii