Memórias do Instituto Oswaldo Cruz (2019) 114 (e190120) - Liaisons dangereuses:

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Patrícia Salgueiro, Johana Restrepo-Zabaleta, Monique Costa, Allan Kardec Ribeiro Galardo, João Pinto, Pascal Gaborit, Amandine Guidez, Ademir Jesus Martins and Isabelle Dusfour (2019)
Liaisons dangereuses: cross-border gene flow and dispersal of insecticide resistance-associated genes in the mosquito Aedes aegypti from Brazil and French Guiana
Memórias do Instituto Oswaldo Cruz 114 (e190120)
Abstract:
BACKGROUND
In recent years, South America has suffered the burden of continuous high impact outbreaks of dengue, chikungunya and Zika. Aedes aegypti is the main mosquito vector of these arboviruses and its control is the only solution to reduce transmission.
OBJECTIVES
In order to improve vector control it is essential to study mosquito population genetics in order to better estimate the population structures and the geneflow among them.
METHODS
We have analysed microsatellites and knockdown resistance (kdr) mutations from a trans-border region in Amazonia between the state of Amapá (Brazil) and French Guiana (overseas territory of France), to provide further knowledge on these issues. These two countries have followed distinct vector control policies since last century. For population genetic analyses we evaluated variability in 13 well-established microsatellites loci in Ae. aegypti from French Guiana (Saint Georges and Cayenne) and Brazil (Oiapoque and Macapá). The occurrence and frequency of kdr mutations in these same populations were accessed by TaqMan genotype assays for the sites 1016 (Val/Ile) and 1534 (Phe/Cys).
FINDINGS
We have detected high levels of gene flow between the closest cross-border samples of Saint-Georges and Oiapoque. These results suggest one common origin of re-colonisation for the populations of French Guiana and Oiapoque in Brazil, and a different source for Macapá, more similar to the other northern Brazilian populations. Genotyping of the kdr mutations revealed distinct patterns for Cayenne and Macapá associated with their different insecticide use history, and an admixture zone between these two patterns in Saint Georges and Oiapoque, in accordance with population genetic results.
MAIN CONCLUSIONS
The present study highlights the need for regional-local vector surveillance and transnational collaboration between neighboring countries to assess the impact of implemented vector control strategies, promote timely actions and develop preparedness plans.
(The abstract is excluded from the Creative Commons licence and has been copied with permission by the publisher.)
Full text of article
Database assignments for author(s): João Pinto, Ademir Jesus Martins, Isabelle Dusfour

Research topic(s) for pests/diseases/weeds:
pesticide resistance of pest
population dynamics/ epidemiology

Pest and/or beneficial records:

Beneficial Pest/Disease/Weed Crop/Product Country Quarant.


Aedes aegypti French Guiana
Aedes aegypti Brazil (NE)
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