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Journal of Virology (2022) 96 (7 - e02140-21)

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Wei Wang, Luqin Qiao, Hong Lu, Xiaofang Chen, Xue Wang, Jinting Yu, Jiaming Zhu, Yan Xiao, Yonghuan Ma, Yao Wu, Wan Zhao and Feng Cui (2022)
Flotillin 2 facilitates the infection of a plant virus in the gut of insect vector
Journal of Virology 96 (7 - e02140-21)
Abstract: Most plant viruses require insect vectors for transmission. One of the key steps for the transmission of persistent-circulative plant viruses is overcoming the gut barrier to enter epithelial cells. To date, little has been known about viral cofactors in gut epithelial cells of insect vectors. Here, we identified flotillin 2 as a plasma membrane protein that facilitates the infection of rice stripe virus (RSV) in its vector, the small brown planthopper. Flotillin 2 displayed a prominent plasma membrane location in midgut epithelial cells. The nucleocapsid protein of RSV and flotillin 2 colocalized on gut microvilli, and a nanomolar affinity existed between the two proteins. Knockout of flotillin 2 impeded the entry of virions into epithelial cells, resulting in a 57% reduction of RSV levels in planthoppers. The knockout of flotillin 2 decreased disease incidence in rice plants fed by viruliferous planthoppers from 40% to 11.7%. Furthermore, flotillin 2 mediated the infection of southern rice black-streaked dwarf virus in its vector, the white-backed planthopper. This work implies the potential of flotillin 2 as a target for controlling the transmission of rice stripe disease.
(The abstract is excluded from the Creative Commons licence and has been copied with permission by the publisher.)
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Database assignments for author(s): Hong Lu

Research topic(s) for pests/diseases/weeds:
transmission/dispersal of plant diseases


Pest and/or beneficial records:

Beneficial Pest/Disease/Weed Crop/Product Country Quarant.


Laodelphax striatellus Rice (Oryza) China (south)
Tenuivirus oryzaclavatae Rice (Oryza) China (NE)