Journal of Medical Entomology (2018) 55, 969-974

Kumudini M. Meepagala, Alden S. Estep, Brandon M. Clausen and James J. Becnel (2018)
Mosquitocidal activity of a naturally occurring isochroman and synthetic analogs from the plant pathogenic fungus, Diaporthe eres against Aedes aegypti (Diptera: Culicidae)
Journal of Medical Entomology 55 (4), 969-974
Abstract: The culture filtrate of a plant pathogenic fungus that infects English ivy (Hedera helix L., Araliaceae) was investigated for mosquitocidal constituents by bioassay-guided isolation. The fungus responsible for pathogenic effects on the plant H. helix has been identified as Diaporthe eres Nitschke by molecular techniques. The mosquito adulticidal constituent in the culture filtrate was identified as 3,4-dihydro-8-hydroxy-3,5-dimethylisocoumarin (1) by spectroscopic techniques. Laboratory bioassays showed that (1) had larvicidal activity against permethrin-susceptible and -resistant Aedes aegypti strains. This compound was not active as an adulticide when tested by topical bioassay. Several analogs of (1) were synthesized and had better mosquitocidal activities than the naturally occurring (1) constituent.
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Link to article at publishers website
Database assignments for author(s): James J. Becnel

Research topic(s) for pests/diseases/weeds:
control - general

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Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Aedes aegypti