Journal of Medical Entomology (2008) 45, 414-420

Julia W. Pridgeon, Liming Zhao, James J. Becnel, Daniel A. Strickman, Gary G. Clark and Kenneth J. Linthicum (2008)
Topically applied AaeIAP1 double-stranded RNA kills female adults of Aedes aegypti
Journal of Medical Entomology 45 (3), 414-420
Abstract: Aedes aegypti (L.) (Diptera: Culicidae) is the primary vector of both dengue and yellow fever. Use of insecticides is one of the primary ways to control this medically important insect pest. However, few new insecticides have been developed for mosquito control in recent years. As a part of our effort to develop new insecticides to control mosquitoes, an inhibitor of apoptosis protein 1 gene in Aedes aegypti (AaeIAP1) was targeted for the development of molecular pesticides. Herein, for the first time, we report that topically applied AaeIAP1 double-stranded RNA products are able to kill female adults of Ae. aegypti. Our results indicate that critical pathways or genes could be targeted to develop molecular pesticides for the control of medically important diseases vectors.
(The abstract is excluded from the Creative Commons licence and has been copied with permission by the publisher.)
Link to article at publishers website
Database assignments for author(s): Julia W. Pridgeon, James J. Becnel, Gary G. Clark

Research topic(s) for pests/diseases/weeds:
control - general

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Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Aedes aegypti