International Journal of Pest Management (2007) 53, 265-272

Colin V. Prescott, Alan P. Buckle, Iftikhar Hussain and Stefan Endepols (2007)
A standardised BCR resistance test for all anticoagulant rodenticides
International Journal of Pest Management 53 (4), 265-272
Abstract: This paper presents a reappraisal of the blood clotting response (BCR) tests for anticoagulant rodenticides, and proposes a standardised methodology for identifying and quantifying physiological resistance in populations of rodent species. The standardisation is based on the International Normalised Ratio, which is standardised against a WHO international reference preparation of thromboplastin, and allows comparison of data obtained using different thromboplastin reagents. The methodology is statistically sound, being based on the 50% response, and has been validated against the Norway rat (Rattus norvegicus) and the house mouse (Mus domesticus). Susceptibility baseline data are presented for warfarin, diphacinone, chlorophacinone and coumatetralyl against the Norway rat, and for bromadiolone, difenacoum, difethialone, flocoumafen and brodifacoum against the Norway rat and the house mouse. A `test dose ' of twice the ED₅₀ can be used for initial identification of resistance, and will provide a similar level of information to previously published methods. Higher multiples of the ED₅₀ can be used to assess the resistance factor, and to predict the likely impact on field control.
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Link to article at publishers website

Research topic(s) for pests/diseases/weeds:
pesticide resistance of pest

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Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Mus musculus
	Rattus norvegicus