FEMS Microbiology Letters (2017) 364 (3 - fnw287)

Shuang-Shuang Zhao, Ying-Ying Zhang, Wei Yan, Ling-Ling Cao, Yu Xiao and Yong-Hao Ye (2017)
Chaetomium globosum CDW7, a potential biological control strain and its antifungal metabolites
FEMS Microbiology Letters 364 (3 - fnw287)
Abstract: Screening for endophytic fungi with antifungal activity is an effective strategy for the discovery of novel biopesticides. Our previous work indicated that Chaetomium globosum CDW7, an endophyte from Ginkgo biloba, exhibited strong inhibitory activity against plant pathogenic fungi in vitro. In this study, we evaluated the CDW7 strain for its antifungal activities against nine phytopathogenic fungi and its biocontrol potential against rape sclerotinia rot caused by Sclerotinia sclerotiorum. The fermentation broth of CDW7 could successfully inhibit disease development in S. sclerotiorum-infected rape in vivo with 57.8% protective efficiency, which is comparable to that of carbendazim (59.8%) at 250 μg mL^-1. The fermentation broth also expressed significant activity stability when exposed to 60°C and UV illumination, or when stored at 4°C. Furthermore, we found that 10% fermentation broth can promote the germination and growth of rape seedlings. Followed by the bioassay-guided approach, seven known metabolites were isolated and identified by spectroscopic analyses. Among them, chaetoglobosin A and D exhibited inhibitory activity against S. sclerotiorum with IC₅₀ values of 0.35 and 0.62 μg mL^-1, respectively, compared with carbendazim (0.17 μg mL^-1). Therefore, our study demonstrated that CDW7 is a promising biocontrol fungus against S. sclerotiorum in agriculture.
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Research topic(s) for pests/diseases/weeds:
biocontrol - natural enemies
Research topic(s) for beneficials or antagonists:
general biology - morphology - evolution

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Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Sclerotinia sclerotiorum	Rape/canola (Brassica napus)
Chaetomium globosum (antagonist)	Sclerotinia sclerotiorum	Rape/canola (Brassica napus)