Acta Entomologica Sinica (2002) 45, 204-208

Guo-Lei Feng, Yun-Zhuan He, Mei Li, Feng-Qin He and Zhang-Wu Zhao (2002)
Relationship between the release of ³H-norepinephrin and the pyrethroid-resistance in houseflies (Musca domestica)
Acta Entomologica Sinica 45 (2), 204-208
Abstract: The release of ³H-labeled norepinephrin was used to assess the effect of selected neurotoxins on synaptosomes from brains of the susceptible (SP), deltamethrin-resistant (Del-R) and permethrin-resistant (2Cl-R) houseflies. A reproducible release of ³H-neurotransmitter was evoked by pulsed-depolarization in the presence of elevated K⁺ (55 mol/ L). The enhanced ³H-norepinephrin release from housefly synaptosomes of Del-R and 2Cl-R reduced by 47.0% and 51.0% respectively in comparison with that from the susceptible strain. The synaptosomes pretreated with 10^-5 mol/L deltamethrin in SP, Del-R and 2Cl-R strains resulted in 80.3%, 26.5% and 70.5% enhancement of ³H-neurotrans-mitter release during pulsed-depolarization, respectively. These results were consistent with the hypothesis that knocked down resistance is most likely due to a decreased affinity, of the voltage-gated sodium channel for deltamethrin. However, the resistance against permethrin showed little effect on synaptosomal efflux of ³H-norepinephrin.
(The abstract is excluded from the Creative Commons licence and has been copied with permission by the publisher.)
(original language: Chinese)

Research topic(s) for pests/diseases/weeds:
pesticide resistance of pest

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Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Musca domestica