FEMS Microbiology Letters (2006) 258, 102-107

Nadia Ponts, Laetitia Pinson-Gadais, Marie-Noëlle Verdal-Bonnin, Christian Barreau and Florence Richard-Forget (2006)
Accumulation of deoxynivalenol and its 15-acetylated form is significantly modulated by oxidative stress in liquid cultures of Fusarium graminearum
FEMS Microbiology Letters 258 (1), 102-107
Abstract: Liquid cultures of Fusarium graminearum were supplemented with H₂O₂ or other oxidative compounds. The accumulation kinetics of the resulting trichothecenes were monitored. At non-lethal concentrations, the H₂O₂ treatments modulated toxin accumulation, dependent on the method of supplementation. When H₂O₂ was added at the same time as the inoculation, higher levels of toxins accumulated 30 days later. Conversely, adding H₂O₂ 2 or 7 days after inoculation had little effect. When H₂O₂ was added daily over the course of the culture, the accumulation of trichothecenes was rapidly and strongly enhanced. The fungus may adapt to oxidative stress when the first exposure to H₂O₂ occurs at the beginning of the culture course. The highest toxin levels were measured when the H₂O₂ was added daily. The importance of the first hours of culture was confirmed: pre-treating conidia with H₂O₂ does not affect their germination kinetics but leads to a reduction in the yield of trichothecenes 40 days later. The H₂O₂ regulation of this trichothecene accumulation may be specific, as paraquat, another pro-oxidant compound, inhibits their production. Since H₂O₂ is a major component of the oxidative burst occurring in pathogen/host interactions, these data support the theory that trichothecenes may act as virulence factors.
(The abstract is excluded from the Creative Commons licence and has been copied with permission by the publisher.)
Link to article at publishers website
Database assignments for author(s): Christian Barreau

Research topic(s) for pests/diseases/weeds:
molecular biology - genes

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Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Fusarium graminearum