Pest Management Science (2013) 69, 397-402

From Pestinfo-Wiki
Revision as of 17:44, 24 March 2013 by Bernhard Zelazny (Talk | contribs) (command-line import)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search

Julie Vein, Danièle Vey, Isabelle Fourel and Philippe Berny (2013)
Bioaccumulation of chlorophacinone in strains of rats resistant to anticoagulants
Pest Management Science 69 (3), 397-402
8th European Vertebrate Pest Management Conference
Abstract: BACKGROUND: Anticoagulants are the only available compounds in the EU to control rat populations. Resistance to anticoagulant rodenticides (antivitamin K or AVK) is described and widespread across Europe. The present objective was to determine whether resistance was associated with an increased potential for bioaccumulation of AVK in the liver. Rats were selected from three major resistant genetically identified strains across Europe: Y139C (Germany), Y139F (France) and L120Q (United Kingdom). The rats were housed in individual cages and fed chlorophacinone wheat bait (50 mg kg−1). Animals were assigned to groups for euthanasia either on day 1, 4, 9 or 14 (resistant rats) or on days 1 and 4 (susceptible rats).
RESULTS: Chlorophacinone accumulated from day 1 to day 4 in all strains (maximum 160 µg liver−1) and remained stable thereafter. There was no significant difference between strains. Extensive metabolism of chlorophacinone was also found, and was similar (in nature and proportion of metabolites) across strains (3 OH-metabolites identified). Only the survival time differed significantly (L120Q > Y139C = Y139F > susceptible).
CONCLUSIONS: Accumulation of chlorophacinone occurs from day 1 to day 4, and an equilibrium is reached, suggesting rapid elimination. Resistant and susceptible rats accumulate chlorophacinone to the same extent and only differ in terms of survival times. Resistant rats may then be a threat for non-target species for prolonged periods of time.
(The abstract is excluded from the Creative Commons licence and has been copied with permission by the publisher.)
Link to article at publishers website
Database assignments for author(s): Philippe Berny

Research topic(s) for pests/diseases/weeds:
pesticide resistance of pest

Pest and/or beneficial records:

Beneficial Pest/Disease/Weed Crop/Product Country Quarant.


Rattus (genus) France
Rattus (genus) Germany
Rattus (genus) United Kingdom
Retrieved from "https://wiki.pestinfo.org/w/index.php?title=Pest_Management_Science_(2013)_69,_397-402&oldid=202977"