Journal of Medical Entomology (2010) 47, 172-178

Julia W. Pridgeon, James J. Becnel, Ulrich R. Bernier, Gary G. Clark and Kenneth J. Linthicum (2010)
Structure-activity relationships of 33 carboxamides as toxicants against female Aedes aegypti (Diptera: Culicidae)
Journal of Medical Entomology 47 (2), 172-178
Abstract: Aedes aegypti L. is the primary vector of dengue and yellow fever viruses, and use of aerosolized insecticides is one of the primary ways to control this medically important mosquito. However, few new insecticides have been developed for mosquito control in recent years. As a part of our effort to search for new insecticides to control mosquitoes, toxicities of 33 carboxamides were evaluated against female A. aegypti by topical application. This group included nine different categories of compounds, namely benzamides, phenyl-propenamides, propanamides, butanamides, butenamides, pentanamides, pentenamides, hexanamides, and hexenamides, that exhibited varying levels of toxicity against this mosquito species. The most toxic compound tested was hexahydro-1-(1-oxohexyl)-1H-azepine, with a 24-h LD₅₀ value of 0.4 µg per mosquito, whereas the most toxic compound at the LD₉₅ level was N-ethyl-2-methyl-N-phenyl-benzamide (1.82 µg per mosquito). The least toxic compound was N,N-bis (2-methylpropyl)-3-phenyl-2-propenamide, with LD₅₀ and LD₉₅ values of 15.66 and 72.07 µg per mosquito, respectively. Results from this initial study may prove useful in guiding further carboxamide modifications for the development of potential new insecticides.
(The abstract is excluded from the Creative Commons licence and has been copied with permission by the publisher.)
Link to article at publishers website
Database assignments for author(s): Julia W. Pridgeon, James J. Becnel, Ulrich R. Bernier, Gary G. Clark

Research topic(s) for pests/diseases/weeds:
control - general

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Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Aedes aegypti