Applied Entomology and Zoology (2001) 36, 381-385

Yuji Tsurubuchi, Akira Karasawa, Keiichi Nagata, Toshio Shono and Yoshiaki Kono (2001)
Insecticidal activity of oxadiazine insecticide indoxacarb and its N-decarbomethoxylated metabolite and their modulations of voltage-gated sodium channels
Applied Entomology and Zoology 36 (3), 381-385
Abstract: Insecticidal bioassays on Plutella xylostella (Linneaus) of an oxadiazine insecticide indoxacarb and its N-decarbomethoxylated metabolite (DCJW), and their modulation of voltage-gated sodium channels in rat dorsal root ganglion neurons were examined. No significant difference was observed in insecticidal activity between indoxacarb and DOW in ingestion and contact tests. In patch-clamp experiments, both indoxacarb and DOW suppressed the peak sodium currents in a time- and dose-dependent manner. DCJW at 1µM blocked the sodium currents to 62.7±3.0% (n=5) of the control after 25 min of bath application. In contrast, in the presence of 1 µM indoxacarb, currents were blocked to 4.5±0.6% (n=4) of control. Thus, the potency of DCJW in blocking sodium currents was higher than that of indoxacarb in rat dorsal root ganglion neurons.
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Database assignments for author(s): Yoshiaki Kono

Research topic(s) for pests/diseases/weeds:
control - general

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Pest and/or beneficial records:

Beneficial	Pest/Disease/Weed	Crop/Product	Country	Quarant.
	Plutella xylostella