Pesticide Science (1997) 50, 312-318

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Regine Blattner, Philippa J. Gerard and Margarethe Spindler-Barth (1997)
Synthesis and biological activity of allosamidin and allosamidin analogues
Pesticide Science 50 (4), 312-318
Abstract: The chitinase inhibitor/insect ecdysis inhibitor allosamidin and eight allosamidin analogues have been synthesised from simple carbohydrate starting materials. Allosamidin was assayed against Tineola bisselliella (Hummel) larvae and all nine compounds were examined for their effects on the development of larvae of Lucilia cuprina (Wiedemann). High larval mortality compared to controls resulted when T. bisselliella and L. cuprina larva were exposed to allosami-din. The (1->3) linked regioisomer, the dimeric analogue and the gluco-configurated dimeric analogue of allosamidin all showed high activity against L. cuprina larvae. The regioisomer, the (1->3) linked isomer and its dimeric analogue, as well as the monomer allosamizoline and its regioisomer, were inactive. These new in-vivo results are consistent with known in-vitro insect chitinase inhibition data, in that greatest larval mortality was exhibited by the best inhibitors.
(The abstract is excluded from the Creative Commons licence and has been copied with permission by the publisher.)
Database assignments for author(s): Philippa J. Gerard

Research topic(s) for pests/diseases/weeds:
control - general

Pest and/or beneficial records:

Beneficial Pest/Disease/Weed Crop/Product Country Quarant.

Tineola bisselliella
Lucilia cuprina