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The genus contains more than 10 species of herbaceous and poisonous plants. Several are important agricultural weeds like jimsonweed, Datura stramonium, or fierce thornapple, D. ferox. These affect crops like maize, cotton or vegetables.
The plants grow up to a height of around 1 m and have egg-shaped or spherical fruits that are covered with sharp spines. The fruits and trumpet-shaped flowers are very poisonous. The latter are typically white or partly purple.
Currently, the following weed species have been entered into the system: