Annual Review of Phytopathology (2013) 51, 383-406

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Sebastian Schornack, Matthew J. Moscou, Eric R. Ward and Diana M. Horvath (2013)
Engineering plant disease resistance based on TAL effectors
Annual Review of Phytopathology 51, 383-406
Abstract: Transcription activator-like (TAL) effectors are encoded by plant-pathogenic bacteria and induce expression of plant host genes. TAL effectors bind DNA on the basis of a unique code that specifies binding of amino acid residues in repeat units to particular DNA bases in a one-to-one correspondence. This code can be used to predict binding sites of natural TAL effectors and to design novel synthetic DNA-binding domains for targeted genome manipulation. Natural mechanisms of resistance in plants against TAL effector-containing pathogens have given insights into new strategies for disease control.
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