The fleas of this family are blood-sucking ectoparasites of mammals and birds. Some are diseases vectors. The family includes, for example, the hen flea, Ceratophyllus gallinae which parasitizes chicken in temperate and subtropical regions, or the rock squirrel flea (Oropsylla montana) which is a vector of sylvatic plague in North America. An important distinguishing feature to the family Pulicidae is the lack of a row of small spine-like bristles on the inner side of the hind coxae.
The following genera are currently entered under this family: